Pain Management in Midtown Manhattan
Personalized treatment for acute and chronic pain in Midtown Manhattan with targeted, non-surgical options and one-on-one physician-led care.
Expert Pain Management That Focuses on the Source of Your Pain
The pain is still there, affecting how you move, work, and get through your day. You may have tried medication, physical therapy, or rest, but the results haven’t lasted. If you’re looking for pain management in Manhattan, you’re likely trying to find an effective and lasting solution.
At Lisa Makrides, MD, PC, you receive physician-led care focused on identifying the source of your pain and building a plan based on your diagnosis. Located in Midtown Manhattan, our appointment-only practice serves patients across Midtown South, the Garment District, and surrounding NYC areas, including Hudson County, NJ.
Our focus is simple: targeted, non-surgical treatment designed to reduce pain and help you function better day to day.
What Does a Pain Management Specialist Do?
A pain management specialist identifies the source of your pain and uses targeted treatments to reduce symptoms and improve function. At Lisa Makrides, MD, PC, that starts with a one-on-one conversation focused on what you’re experiencing and how it’s affecting your life.
Your care is built around clear priorities:
- Pinpointing the source of your pain and contributing factors
- Reviewing past treatments and why they did or did not work
- Recommending targeted options such as injections or non-surgical therapies
- Building a plan focused on improving movement and daily function
If your pain has not improved with standard care, Dr. Makrides outlines the next steps based on your diagnosis and goals.
We focus on identifying the cause of your pain and choosing treatments that improve function without unnecessary escalation.
Conditions We Treat From Our Manhattan Office
Pain shows up in different ways, but when it starts to limit your routine, it's worth looking at available solutions. Care focuses on identifying the root cause and treating it with targeted interventions.
Common conditions include:
- Back pain, knee and shoulder pain
- Neck pain and limited mobility
- Joint pain related to arthritis or inflammation
- Nerve pain with radiating or burning symptoms
- Fibromyalgia and chronic pain syndromes
- Sports injuries and overuse conditions
- Complex regional pain syndrome
- Plantar fasciitis treatment
Relief starts with understanding what’s actually causing the problem and what treatment options are appropriate.
Pain Management Treatments Available in Midtown Manhattan
Treatment is based on your diagnosis, history, and response to prior care. The goal is to use targeted options that improve function and reduce pain while avoiding unnecessary escalation.
Interventional Pain Management for Targeted Relief
Interventional pain management uses procedures such as injections and nerve blocks to treat specific sources of pain. It is commonly used for spinal conditions, joint pain, and nerve-related symptoms. These treatments can reduce inflammation and improve mobility.
Ketamine Therapy as a Supportive Option for Chronic Pain
Ketamine therapy may be considered for certain chronic pain conditions that have not responded to standard treatment. It acts on NMDA receptors involved in pain signaling and sensitization. In selected patients, it may help reduce central pain amplification as part of a broader plan.
Regenerative Medicine for Joint and Tissue-Related Pain
Regenerative medicine focuses on supporting the body’s natural healing response using treatments such as platelet-rich plasma (PRP) and other biologic therapies. It is often used for joint pain, soft tissue injuries, and chronic musculoskeletal conditions. The goal is to improve tissue function and reduce pain over time.
Prolotherapy for Joint Instability and Chronic Pain
Prolotherapy uses targeted injections to stimulate a healing response in weakened connective tissue. It is commonly used for ligament laxity, joint instability, and certain chronic pain conditions. This approach aims to improve structural support and long-term function.
Neuromodulation for Chronic Nerve & Pain Signal Management
Neuromodulation
uses electrical stimulation to alter how pain signals are processed by the nervous system. It is typically considered for chronic nerve pain or conditions that have not responded to other treatments. The goal is to reduce pain perception and improve daily function.
Medication Management, Including Medical Marijuana
Medication management is used to help control pain symptoms as part of a structured treatment plan. This may include traditional medications or, when appropriate, medical marijuana for certain chronic pain conditions. The focus is careful selection, monitoring, and adjustment based on your response.
Focused, Physician-Led Approach to Pain Management
Certified by the American Board of Pain Medicine & American Society of Interventional Pain Physicians
Your care is led directly by a physician with over a decade of experience in anesthesiology and pain management. Dr. Makrides earned her medical degree from Thomas Jefferson Medical College, completed anesthesiology training, and has been practicing since 2008. Her experience includes clinical training in New York City at Mount Sinai Hospital in Manhattan.
You work with one provider who reviews your history, prior treatments, and symptoms in detail, then builds a plan based on your diagnosis. You are not moved between providers or placed into a standard treatment track.
“She is the only pain management specialist that has ever spent the time to listen and develop a plan…” — Terry D.
Serving Midtown Manhattan, Midtown South, and the Surrounding Area
The office is located at 240 W 37th St in Midtown Manhattan, within the Garment District and close to Penn Station and major transit lines.
Patients visit from across Midtown Manhattan, Midtown South, Downtown Manhattan, and nearby areas in Hudson County, NJ. All visits are by appointment only, allowing for focused, one-on-one care.
What to Expect From Your First Appointment
Your first visit is focused on understanding your pain and outlining the next steps.
- You explain your symptoms and how they affect daily life
- You review past treatments and results
- You identify the likely source of the pain
- You receive a clear plan based on your condition and goals
You leave with a better understanding of your pain and what comes next.
When Should You See a Pain Management Doctor?
You do not need to wait until pain becomes severe. Earlier evaluation can lead to more effective treatment options.
It may be time to seek care if:
- Pain is not improving with time or basic care
- Symptoms keep returning or worsening
- Daily activities or sleep are affected
- Previous treatments have not provided enough relief
- You want to avoid surgery or stronger medications
If your progress has stalled, it may be time to take a closer look.
Pain Management FAQs
Do You Need Imaging or a Diagnosis Before Seeing a Pain Management Specialist?
No. Many patients are evaluated without prior imaging, and testing is only recommended if it helps confirm a diagnosis or guide treatment decisions.
Is Ketamine Therapy Safe for Chronic Pain Treatment?
Ketamine therapy is used selectively for certain chronic pain conditions and is administered under medical supervision. It works differently than traditional medications and may help reduce central pain sensitization in carefully selected patients.
How Do You Know If Your Pain Is Nerve-Related or Structural?
Nerve pain often feels burning, tingling, or radiating, while structural pain is more localized and linked to movement or joint use. A clinical evaluation, and sometimes imaging, is used to determine the source.
What Are the Most Effective Non-Surgical Treatments for Chronic Pain?
Non-surgical treatments may include injections, nerve blocks, and regenerative therapies such as prolotherapy. The most effective option depends on the diagnosis, severity, and response to prior care.
You Don’t Have to Keep Living With Unresolved Pain
If your pain isn’t improving or keeps returning, it may be time for a different approach. At Lisa Makrides, MD, PC, you’ll receive physician-led care focused on understanding your condition and outlining clear next steps.
If you’re looking for pain management in Manhattan, request your appointment today and start with a one-on-one evaluation.
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