Ketamine Therapy In Harrisburg, PA

Get Ketamine Relief Today

How Does Ketamine Work?

Ketamine works in the body by targeting key receptor sites in the brain to protect against excitotoxicity and restore balance in how information is processed. Research has revealed how ketamine's effects go beyond acting on glutamate receptors; it also influences areas tied to motivation, emotion, and behavior, including monoamine transporters and opioid receptors, allowing it to target a wider array of symptoms quickly. Those seeking help managing their mental health condition can rest assured that ketamine is a safe and effective option to explore.

More Options for Conditions That Aren’t Simple to Treat

Makrides Aesthetics offers ketamine infusion therapy in the Harrisburg area. With ketamine therapy, patients suffering from treatment-resistant depression, chronic pain, and other debilitating conditions can finally find relief. Unlike other interventions, ketamine infusion treatments can take effect almost immediately. 


Founded by Dr. Lisa Makrides, a board-certified anesthesiologist and cosmetic physician, Makrides Aesthetics uses a personalized, evidence-based approach to treat serious mental and physical health conditions safely and effectively.

Find Relief Today

The Science Behind Ketamine Therapy

Ketamine acts mainly on the NMDA receptor system and affects pain processing involved in mood regulation. It’s a well-established medicine used in procedural and hospital settings, and it helps manage certain mental health and chronic pain conditions. At Makrides Aesthetics, we offer ketamine therapy in a highly controlled medical environment with physician oversight and individualized protocols.

Using Ketamine for Pain & Mental Health Care

Ketamine isn’t a first-line treatment. Our team offers it only after reviewing previous treatments and a thorough evaluation.

Clinical Uses

Ketamine therapy may be considered for those with ongoing symptoms that haven’t responded to traditional treatments, such as:

Chronic Pain

Ketamine may be incorporated into a broader pain-management plan for certain conditions involving neuropathic pain or central sensitization, including: 

    • Neuropathic pain syndromes
    • Complex regional pain syndrome (CRPS)
    • Chronic spine-related pain
    • Other chronic pain conditions refractory to standard treatment

    **Therapy is intended to reduce abnormal pain signaling and improve overall function, not to replace ongoing multidisciplinary care.

    Mental Health Conditions

    When clinically appropriate, ketamine may be used to help manage:

      • Treatment-Resistant Depression
      • Severe Anxiety Disorders 
      • PTSD & Stress Disorders
      • Addiction & Relapse Prevention

      “She has changed my life, and I couldn’t be happier with her. I went from barely being able to walk to enjoying outdoor activities again.” –Michael H.

      Find Out If Ketamine Is Right For You

      A Look Inside Your

      Ketamine Infusion Therapy Experience

      Preparing You for a Safe Treatment

      Patients go through a comprehensive medical and psychiatric screening, which may include:


      • Review of health history and previous treatments
      • Review of current medications
      • Discussion of treatment goals and whether ketamine may be appropriate


      **Ketamine therapy is provided only when clinically indicated and medically appropriate.

      Your Time in the Treatment Suite

      Treatment takes place in a quiet, private setting designed for patient comfort. Staff monitor vital signs throughout the session and provide direct medical supervision from start to finish. 

      

      Depending on the formulation and treatment protocol, sessions generally last 40–90 minutes. Some patients experience temporary relaxation or changes in perception during treatment. These effects are anticipated, closely monitored, and typically resolve after the session.

      Planning Your Ongoing Care

      After treatment, staff monitor patients until they are medically stable and ready to leave. Patients may not drive for the remainder of the day. We discuss follow-up care and next steps based on each patient’s individual treatment plan.

      

      Ketamine therapy is commonly provided over multiple sessions, allowing the physician to assess response and make treatment decisions over time rather than relying on a single treatment.

      Ketamine Administration Options

      Dr. Makrides determines the most appropriate formulation and dose for each patient based on their medical history, condition, and specific treatment needs.

      Intravenous (IV) Ketamine

      Administered through a controlled infusion in a monitored setting, IV ketamine allows for precise titration and a predictable onset. It's commonly used for chronic pain and mood disorders.

      Intramuscular (IM) Ketamine

      Delivered via injection into a large muscle, IM ketamine offers predictable absorption without needing IV access. This option is suitable for selected patients based on clinical judgment.

      Intranasal Ketamine

      This non-invasive nasal spray is administered under medical guidance and is used in select mental health protocols, providing a convenient option for patients.

      Oral / Sublingual Ketamine

      Taken by mouth or absorbed under the tongue, this method has lower bioavailability and a slower onset. It's typically reserved for maintenance or carefully selected cases.

      Commitment to Safety & Discretion

      Your safety and privacy remain central throughout treatment. Dr. Makrides brings extensive experience in anesthesiology and pain medicine, providing physician-directed ketamine therapy with careful screening, individualized dosing, ongoing monitoring, and discreet, attentive care. 

      Get Expert Ketamine Therapy

      Ketamine Therapy Pricing: What to Expect

      Ketamine therapy costs in Harrisburg, PA, vary by treatment approach, number of sessions, and individual care plan. During your consultation, we’ll discuss recommended treatment, expected costs, and available payment options so you can plan appropriately.


      “Dr. Makrides has been helpful, professional, and the backbone of my care. She takes her time with me, very accessible if needed, will go out of her way to make sure that I get any referrals done at the time of service.”


      –Terra R. 

      Frequently Asked Questions About Ketamine Therapy

      Ketamine therapy costs in Harrisburg, PA, vary based on the treatment approach, number of sessions, and individual care plan. During your consultation, we’ll discuss recommended treatment, expected costs, and available payment options so you can plan appropriately.

      • 1. How Do I Know If Ketamine Therapy Is Worth Exploring?

        Ketamine may be considered when certain chronic pain or mental health symptoms persist despite conventional treatment. Dr. Makrides reviews your health history, previous treatments, current medications, and goals to determine whether ketamine is a medically appropriate option for you.


      • 2. How Quickly Will I Know If Ketamine Is Working?

        Response to ketamine varies from patient to patient. Some individuals may notice changes sooner than others, while some may not experience meaningful improvement. Dr. Makrides evaluates your response over time rather than relying on a single session.


      • 3. What Should I Do Before a Ketamine Treatment?

        You’ll receive specific instructions based on your treatment plan and method of administration. Before beginning therapy, we review your medical history, medications, previous treatments, and other relevant factors to determine an appropriate and safe approach.


      • 4. Can I Go Back to Work After Ketamine Therapy?

        Plan for downtime after your appointment. Ketamine can temporarily affect alertness, coordination, and perception, and same-day driving is not permitted. Dr. Makrides will provide instructions about returning to work and other normal activities based on your treatment.


      • 5. Does Insurance Pay for Ketamine Therapy?

        Insurance coverage for ketamine therapy varies by provider, plan, condition, and treatment type. Some services may not be covered. We recommend contacting your insurance provider directly to understand your benefits and any potential out-of-pocket costs before beginning treatment. 


      • 6. What Happens If Ketamine Doesn’t Help My Symptoms?

        Ketamine does not work for everyone, and results cannot be guaranteed. Your response is monitored throughout treatment so Dr. Makrides can determine whether to continue, modify, or reconsider the treatment approach.


      Another Approach to Pain Management

      When other pain management options haven’t provided the relief you hoped for, ketamine therapy may be worth exploring. At Makrides Aesthetics, we help patients throughout the Harrisburg area understand their options through personalized, physician-directed care. Schedule a consultation with Dr. Makrides to find out if ketamine therapy may be appropriate for you. 

      Book Your Appointment

      Looking For Ketamine Treatment Near NYC? 

      We’ve opened a second office in Midtown Manhattan!


      We’re happy to announce the opening of our
      Midtown Manhattan location, which offers the same physician-led ketamine therapy, personalized treatment plans, and compassionate care for patients throughout New York City.

      Book An NYC Appointment